9 hours ago · Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats and more for Colts-49ers.

Dec 24, 2025 · Monday Night Football closes out Week 16 with a huge matchup between the San Francisco 49ers and the Indianapolis Colts.

Live coverage of the San Francisco 49ers vs. Indianapolis Colts NFL game on ESPN, including live score, highlights and updated stats.

8 hours ago · The Sporting News is tracking live scoring updates and highlights for 49ers vs. Colts on "Monday Night Football." Follow for complete results from the NFL Week 16 prime-time game.

6 hours ago · A meeting featuring two of the NFL's best in Christian McCaffrey and Jonathan Taylor will close Week 16 as the 49ers and Colts clash in a matchup with playoff implications.

10 hours ago · The Indianapolis Colts, led by 44-year-old quarterback Philip Rivers, are hosting the San Francisco 49ers on “Monday Night Football.” Follow along for the latest news, updates and …

8 hours ago · The Indianapolis Colts host the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Live score updates, highlights, where to watch.

6 hours ago · The San Francisco 49ers visit the Indianapolis Colts in Week 16 of the NFL season. Follow along for highlights and live score updates.

15 hours ago · The San Francisco 49ers are back in primetime for their Week 16 contest against the Indianapolis Colts. The team released the final injury report ahead of the "Monday Night …

1 day ago · NFL.com's Bobby Kownack breaks down three must-know storylines ahead of Week 16's prime-time game between the San Francisco 49ers and Indianapolis Colts.