Jan 9, 2025 · Chimeric Antigen Receptor (CAR)-T cell therapy has rapidly emerged as a groundbreaking approach in cancer treatment, particularly for hematologic malignancies. However, the application of …

Jan 9, 2025 · We reviewed preclinical experiments and clinical trials involving CAR-T, Car-Treg and CAAR-T cell therapies in various autoimmune diseases. By highlighting these cutting-edge …

Jul 4, 2025 · This review begins with a comprehensive overview of CAR-T cell therapy for cancer, covering the structure of CAR-T cells and the history of their clinical application.

Dec 11, 2025 · A new type of CAR T-cell therapy elicits a more controlled immune response to cancer in mice, effectively killing cancer cells with fewer side effects.

Mar 10, 2025 · Researchers have successfully developed a supercharged iteration of CAR-T cell therapy that can enhance the effectiveness and longevity of the cells, particularly against cancer cells that are ...

Dec 15, 2025 · The one-time therapy’s CAR design includes a CD28 co-stimulatory module to enhance the therapeutic cells’ persistence and potency for a potentially more durable effect.

Off-the-shelf CAR-T cell therapies, leaner manufacturing processes, and combination therapy with mRNA vaccines, oncolytic viruses, and insertable bio-scaffolds are promising developments to make CAR-T …

Oct 1, 2024 · Trials with CAR-T cells with other targets and other hematologic malignancies are currently in development. Given its efficacy in poor prognosis refractory hematologic malignancies, CAR-T cell …

8 hours ago · Chimeric antigen receptor T (CAR-T) cell therapy has revolutionized hematologic cancer treatment, but its efficacy in solid tumors remains limited by poor infiltration into the complex tumor ...

Oct 28, 2023 · Cancer is a worldwide health problem. Nevertheless, new technologies in the immunotherapy field have emerged. Chimeric antigen receptor (CAR) technology is a novel biological …