Dec 24, 2025 · The Colts scored to cut San Francisco’s lead to 34-27 in the fourth quarter, but Shanahan and Purdy went right back to work.

7 hours ago · The San Francisco 49ers finished their Week 16 "Monday Night Football" contest with a 48-27 win over the Indianapolis Colts at Lucas Oil Stadium.

7 hours ago · Highlights from the Week 16 matchup between the San Francisco 49ers and the Indianapolis Colts during the 2025 NFL season.

11 hours ago · Box score for the San Francisco 49ers vs. Indianapolis Colts NFL game from December 22, 2025 on ESPN. Includes all passing, rushing and receiving stats.

6 hours ago · The San Francisco 49ers took care of business Monday night with a 48-27 win over the Indianapolis Colts. It wasn't a perfect victory, but it was a mostly dominant performance from San …

16 hours ago · The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy’s career-high five touchdown passes. Christian McCaffrey racked up 146 …

13 hours ago · What to Know The San Francisco 49ers (11-4) thumped the Indianapolis Colts (8-7) with a 48-27 victory on "Monday Night Football" in Week 16 at Lucas Oil Stadium. Brock Purdy dazzled in …

3 days ago · NFL 49ers 48 vs. 27 Colts summary, stats, score and highlights | NFL Week 16 Brock Purdy threw for five TDs in a Monday Night shootout as the San Francisco 49ers beat the Indianapolis Colts …

14 hours ago · The Indianapolis Colts lose to the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Score updates, highlights

12 hours ago · The San Francisco 49ers offense is cruising and they were dominant in a win over the Indianapolis Colts. Here are the highlights.