Revvity's Dharmacon All-in-one lentiviral platform has expanded to include whole-genome library options for CRISPR knockout (CRISPRko), CRISPR interference (CRISPRi), and CRISPR activation (CRISPRa).

Natural systems such as CRISPR-associated transposons (CASTs) offer a targetable, one-step way to edit genomes. However, adapting them for biomedical applications has been challenging. To address this ...

CRISPR-based screening identifies H2AZ1 as a driver of cellular senescence. (A) Schematic of CRISPR-based loss-of-function (LOF) screening for histone variant-associated genes (HVRGs) to identify ...

The obesity rate has more than doubled in the last 30 years, affecting more than one billion people worldwide. This prevalent condition is also linked to other metabolic disorders, including type 2 ...

CRISPR-based technologies promise transformative therapies, yet their success depends on the purity and quality of guide RNAs (gRNA). During high-throughput screening of candidates, even small ...

This figure shows the structure of PTGES3. The research team made the association after creating a fluorescent tag that tracks androgen receptor levels in real time. The androgen receptor is a hormone ...

This article and associated images are based on a poster originally authored by Donato Tedesco, Tianbing Liu, Dongfang Hu, Nadya Isachenko, Debbie Deng, Paul Diehl and Alex Chenchik and presented at ...